Stem Cell Transplantation

In the specialty of allogeneic and autologous transplants (bone marrow transplantations), Stockholm Care work primarily with the Center for Allogeneic Stem Cell Transplantation (CAST) at Karolinska University Hospital. The clinic’s focus is SCT and other cellular therapies in adults and children. The clinic performed Sweden’s first SCT in 1975, and today approximately 100 SCTs are performed each year.

Allogeneic SCT is used for a number of malignancies, yet also increasingly for non-malignant disorders. The clinical functions of CAST are embedded in a wide range of activities to ensure excellent clinical results. These world-leading results are thanks to fast adaptation of novel methods for transplantation and novel treatment modalities that prevent and treat life-threatening complications, including graft-versus-host-disease (GVHD) or viral infections, such as EBV or CMV infections.

For patients with Remitting and Relapsing Multiple Sclerosis (RRMS), the clinic offers autologous hematopoietic stem cell transplantation (HSCT) in collaboration with the Department of Neurology at the Karolinska University Hospital.

Patients usually stay close to the hospital for up to three months after transplantation in order to prevent and treat post-transplant-related complications. This helps to identify individual solutions, taking into account the level of care and expertise accessible in the patient’s home country.

CAST has a strong partnership with academia and conducts clinical training and collaborates with clinics at Karolinska University Hospital and other health institutions around the world to develop and apply cellular therapies. Research collaborations and clinical training modules can be developed according to the patient’s needs.

The allogenic stem cell transplantation procedure is performed in unison by three clinics, (CAST, department of paediatrics and center for apheresis and stem cell preparation) and together they are accredited according to JACIE, which is an international standard of quality.

Multiple Sclerosis

In collaboration with the Department of Neurology at the Karolinska University Hospital, patients with Remitting and Relapsing Multiple Sclerosis (RRMS) are offered treatment with autologous hematopoietic stem cell transplantation (HSCT) at CAST. Karolinska has more than 30 years´ experience from autologous HSCT and more than 10 years´ experience from treating RRMS with excellent results.

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